The ballad of TIGIT

There exist drug classes that seem, in retrospect, cursed. As these chemicals worm their way through the clinical trial system, they consume billions of dollars along the way, and squelch through thousands of sick patients. When finally it dawns on everyone how useless the whole endeavour was, the drugs life is at last cut short, nothing useful left in its destructive wake. The prototype here are amyloid-beta drugs. These are Alzheimer’s treatments that are widely perceived as immense disappointments, with the negative sentiment even leaking to the broader public.