AI RESEARCH
New Benchmarking Shows Limited Generalization Power of TCR Antigenic Epitope Prediction Models
arXiv CS.LG
•
ArXi:2606.04994v1 Announce Type: new Accurate computational prediction of T cell receptor (TCR) antigen specificity would transform the study of T cell biology and enable scalable immune engineering, yet existing models lack sufficient sensitivity and specificity for broad applications. A major limitation is the absence of rigorously defined, unseen benchmark datasets that allow unbiased evaluation of model performance and generalizability.