Demystifying Multimodal Biomolecular Co-design With Intrinsic Geodesic Coupling

ArXi:2606.01628v1 Announce Type: cross Biomolecules such as proteins and small-molecule ligands play a central role in biological systems, arising from the tight interplay between sequence and three-dimensional structure. Recent generative models for biomolecular co-design aim to capture this interplay by jointly modeling coupled modalities. However, existing approaches largely adopt a parallel execution of marginal generative processes, implicitly enforcing fixed synchronous coupling.