AI RESEARCH
OOD-GraphLLM: Graph Large Language Model for Out-of-Distribution Generalized Drug Synergy Prediction
arXiv CS.LG
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ArXi:2605.30247v1 Announce Type: new Drug synergy prediction (DSP) aims to identify efficacious drug combinations under various cellular contexts with different targets. However, the continual emergence of novel compounds results in variations in molecular scaffolds and sizes, causing drug synergy data to exhibit out-of-distribution (O. O. D.) shifts with respect to topological structure. Existing works rely on in-distribution (I. D.) assumption, failing to handle the O. D. shifts.