AI RESEARCH
Geometry-First Generative Spatial Single-Cell Reconstruction
arXiv CS.LG
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ArXi:2605.28200v1 Announce Type: new Single-cell RNA sequencing (scRNA-seq) profiles large numbers of cells but loses spatial context, whereas spatial transcriptomics (ST) preserves partial spatial structure at lower resolution. Most existing integration methods either deconvolve spot mixtures or map cells onto a measured spot lattice, which ties reconstructions to a fixed grid and slide-specific coordinate systems, a limitation that is especially problematic in unpaired settings.