WTKO-CNN: Deep Learning Reveals Sequence Motifs Distinguishing Wild-Type and Knockout ATAC-seq Peaks

ArXi:2605.24034v1 Announce Type: cross Chromatin regulators can alter transcriptional programs by modifying the accessibility of regulatory DNA elements. Understanding how regulatory sequences differ between wild-type (WT) and knockout (KO) conditions is crucial for deciphering transcriptional control. Here, we applied a convolutional neural network, \textbf{WTKO-CNN} with an attention mechanism to classify DNA sequences as WT or KO, achieving high predictive performance.