A large-scale unified deep learning model for peptide mass spectrum interpretation trained on multimodal data

Nature Machine Intelligence, Published online: 25 May 2026; doi:10.1038/s42256-026-01234-8 pUniFind is a large-scale deep learning model for proteomics that unifies peptide-spectrum scoring and open de novo sequencing. Trained on over 100M spectra, it substantially improves peptide identification and modification discovery.