AI RESEARCH
AgForce Enables Antigen-conditioned Generative Antibody Design
arXiv CS.LG
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ArXi:2605.21610v1 Announce Type: new Antibody design methods condition on antigen structure to generate complementarity-determining regions (CDR), yet a systematic evaluation of baseline methods reveals that they largely ignore the antigen input. We identify three failure modes that explain this behavior. Antigen blindness arises because models derive predictions from antibody framework context rather than antigen information, producing nearly identical CDRs regardless of the target.