AI RESEARCH
ConTact: Contact-First Antibody CDR Design via Explicit Interface Reasoning
arXiv CS.LG
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ArXi:2605.21600v1 Announce Type: new Computational antibody CDR design methods condition on antigen structure to generate binding loops, yet existing architectures conflate two fundamentally distinct sub-problems: identifying which CDR positions will contact the antigen, and selecting amino acids at those positions. This conflation forces models to learn contact reasoning implicitly through uniform message passing, diluting antigen signal across all positions equally. We