AOP-Wiki EMOD 3.0: Data Model Expansions and Content Evaluation Framework for Using Agentic AI to Improve Integration between AOPs and New Approach Methodologies (NAMs)

ArXi:2605.21645v1 Announce Type: new Adverse Outcome Pathways (AOP) are logic models that causally link biological mechanisms that can be measured in a lab to adverse outcomes, relevant to chemical regulatory endpoints. AOPs contextualize new approach methodologies (NAMs), in vitro and in silico methods used as alternatives to animal testing and the sequential events in an AOP serve as multi-scale models spanning biological scales. The AOP-Wiki serves as the global repository for AOPs.